Home Medicine Study 7 Autoimmune Diseases Biotechs are Fighting to Treat

7 Autoimmune Diseases Biotechs are Fighting to Treat


5. Addison’s Disease

Addison’s disease is an ailment that occurs due to deregulations within the endocrine system, the system responsible for controlling the release of hormones. It is triggered by 21-hydroxylase, an enzyme that attacks the adrenal glands and prevents it from generating adrenaline and cortisol, two essential hormones.

This leads to a series of awful symptoms, such as fatigue, weakness, hyperpigmentation of the skin, pain, and salt loss, which also triggers low blood pressure levels. When the hormone levels get significantly low, it can even trigger acute attacks.

Addison's disease and type 2 diabetes
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Doctors commonly treat the Addison’s disease with regular sessions of hormone replacement therapy that provides a replacement for cortisol. However, this can be extremely challenge, for instance, diabetic patients are forced to keep syringes of cortisol with them at all times in case of an emergency.

Researchers from Queen Mary University have discovered an alternative treatment to eliminate Addison’s disease by fulfilling the cortisol levels in the body through urine cells to trigger the development of an artificial adrenal gland.

6. Vitiligo

Most people tend to believe that Vitiligo is a hyperpigmentation that alters the color of the skin, but the truth is quite the opposite: Vitiligo is actually the loss of skin pigment. Chantelle Brown, an inspiring supermodel, has opened up the space for discussion by recounting her story of living with vitiligo and how it has affected her health, and exposed her to various cruel social stigmas surrounding her facial beauty.

Doctors commonly prescribe light therapy and corticosteroids to eliminate the symptoms of vitiligo, but these therapies induce premature skin aging and elevate the risk factors of suffering from skin cancers. Consuming corticosteroids for a long period of time comes with its own distinctive side-effects, including increasing the risk factors of suffering from diabetes, osteoporosis, and infections. It is imperative to research and identify safer alternative treatments and medications that eliminate the symptoms without inducing any side effects.

Vitiligo pain
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European biotech researchers are leading the developments with promising results. Vilacta Bio, a Denmark-based biotech organization, is working on creating skin lotions that can eliminate the symptoms of vitiligo by boosting the immune system with its nanoparticle drug-delivery technology.

Researchers from the University of Navarra conducted a Phase I/II trial, which revealed that grafting melanocytes extracted from patients upon the affected skin areas can aid in curing vitiligo. Clinuvel Pharmaceuticals, an Australian biopharma organization, has also produced promising results with SCENESSE, a phase II testing.


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